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Coffee should be avoided by those who are Celiac and many who suffer from wheat sensitivity as it contains cross-reactive proteins to gluten.

If you drink coffee, even bulletproof coffee and have gluten sensitivity or celiac, you might want to sit down for this one.
There is a surprising connection between gluten and coffee that is by and large ignored by the health community. This revelation holds ramifications for other autoimmune disorders as well.
The problem has nothing to do with caffeine, so decaf coffee would be included in this discussion.
In a nutshell, fairly recent lab research has revealed that 10% of coffee is a protein that cross-reacts with gluten antibodies.
This means that if you are gluten sensitive or celiac and are avoiding gluten-containing grains or perhaps have even gone completely grain-free if you still drink coffee there is a strong likelihood that the protein in the coffee is triggering the very same gluten-related health problems you are trying to avoid.
In other words, even if you think you are doing fine with your current gluten-free diet, it is very possible that skipping the coffee could take your health to the next level.
Symptoms of Gluten Sensitivity
Most people who are gluten sensitive don’t realize it because gastrointestinal problems like burping, gas, tummy upset, or toilet issues are the least common way for gluten issues to present themselves!
The most common symptoms of gluten sensitivity?
Migraines and other neurological issues – even MS!
Hormone and endocrine problems are another common way for gluten issues to manifest themselves.
How Coffee Triggers Gluten Sensitivity
So what exactly happens when a gluten sensitive person eats gluten?
Folks with gluten antibodies react to any gluten in the diet by mounting an immune response. This means that gluten is perceived by the body as an invader and the gluten antibodies attack the gluten itself trying to destroy it. This gluten attack is an inflammatory response and inflammation issues can occur anywhere in the body in any tissue or organ.
Here’s the real shocker I came across when researching the coffee/gluten connection:
According to Dr. David Clark DC, functional neurologist and endocrinologist:
There’s not a disease or health condition you can think of that does not have an association – in the research literature – with gluten sensitivity.
That’s a very strong statement!
In essence then, if you are gluten sensitive in any way shape or form, and it seems that most people are whether they know it or not given the epidemic levels of autoimmune issues today, gluten antibodies have the potential to react to proteins in other foods as if they are gluten thereby triggering an immune and inflammatory response.
The protein in coffee is the most common cross-reactor for gluten. Because it is the protein in the coffee that is the trigger, switching to decaf coffee does not solve the problem. Apparently, instant coffee is the worst offender.
Is it possible to be gluten sensitive and not cross-react to coffee? Yes, it’s possible but you’ll have to do some expensive lab testing with a knowledgeable doctor to find out.

Reference
Journal of Food and Nutrition Sciences
More Information
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Coffee Enema
Morning Coffee Fix
Caffeine and Chronic Back Pain
Healthy Coffee Substitutes
Coffee is a beverage to avoid for Hashimoto patients who normally have leaky gut and are gluten intolerant. Thanks for sharing the information.
http://thyroidbook.com/blog/autoimmune-gut-repair-diet/
Good point.
@Laura yes I think Paleos are so into coffee because many are thyroid depressed from not eating any grains and being so low carb. I was off grains for 6 months and felt great (healed up my gut) and then was getting sooo tired I i knew it was time to go back on grains.
I am really surprised how coffee crazy paleo folks tend to be.
Dislike!
I’m truly depressed now, I love my morning cup of freshly brewed Panamanian! Guess I should now say that in the past tense. 🙁
…Chris did mention it on his podcast of 13th June 2012 but rather he was not at that time convinced of its clinical relevance. Is the cross reactivity due to underlying intestinal permeability problems associated with gluten sensitivity or is it a true cross reactivity due to similar protein structures? Is it likely people who are gluten sensitive then cross react to many other proteins too? The significance of what Cyrex labs concludes is not really clear. He also recommends removing coffee if you are gluten sensitive and seeing if any symptoms subside or you just generally feel better. No more evidence is really required other than direct personal experience of an individual I guess! Interesting topic!
This is very true! I was tested for gluten sensitivities, which I have. Coffee was the highest reaction I had, my body thinks coffee is gluten.
This is very true! I was tested for gluten sensitivities, which I have. Coffee was the highest reaction I had, my body thinks coffee is gluten.
Coffee is harmful. Common sense tells us this.